Trimethyltin chloride

Synonyms

Chlorotrimethylstannane; Chlorotrimethyltin; M&T Chemicals 1222-45; Stannane, chlorotrimethyl-; Stannylium, trimethyl-, chloride; Tin(1+), trimethyl-, chloride; Trimethylchlorostannane; Trimethylchlorotin; Trimethylstannyl chloride; [ChemIDplus] UN3146

Category

Tin Compounds, Organic

Description

Colorless solid; mp = 37.5 deg C; [HSDB] White crystalline solid; [MSDSonline]

Sources/Uses

A byproduct of methyltin manufacture; Used as an experimental pesticide; [HSDB]

Comments

In 1981, six employees in a chemical firm were exposed to trimethyltin chloride while working at the access opening of the reactor. All patients were hospitalized, and one patient died 10 days after the accident. Patients had headache, tiredness, hearing loss, disorientation, and other neurological symptoms. [HSDB] Of the trialkyltins, triethyltin and trimethytin are the most toxic. [ACGIH] An irritant; Can be absorbed through skin; [MSDSonline] See "Tin, organic compounds."

Biomedical References

Yes

0.1 mg/m3, as Sn

0.2 mg/m3, as Sn

0.1 mg/m3, as Sn

0.005 mg/m3 (can also occur as vapor and aerosol)

25 mg/m3, as Sn

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organotin compound, solid, n.o.s." Organic tin compounds have a "skin" designation and are classified as "A4" (Not classifiable as human carcinogen); [ACGIH]

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, acute toxic