1,2-Diphenylhydrazine

Synonyms

(sym)-Diphenylhydrazine; 1,1'-Hydrazodibenzene; Benzene, 1,1'-hydrazobis-; Benzene, hydrazodi-; Hydrazobenzen [Czech]; Hydrazobenzene; N,N'-Bianiline; N,N'-Diphenylhydrazine; Symmetrical diphenyl hydrazine; 1,2-Diphenylhydrazine (9CI); Hydrazine, 1,2-diphenyl-; [ChemIDplus]

Category

Hydrazines

Description

Orange powder or a bright orange crystalline solid; [CAMEO]

Sources/Uses

Used in the past in the United States to produce benzidine; the last manufacturer of benzidine-based dyes in the U.S. ceased production in 1988; Used as an intermediate in the pharmaceutical industry to produce phenylbutazone and sulfinpyrazone; [ATSDR ToxProfiles]

Comments

"1,2-Diphenylhydrazine oxidizes rapidly in the environment under aerobic conditions, with a half-life in water as short as 15 minutes. . . . it is possible that 1,2-diphenylhydrazine may cause methemoglobin in humans. However this would occur only if sufficient aniline were formed rapidly enough to exceed the capacity of methemoglobin reductase to reduce methemoglobin." Hepatic effects have been observed in high-dose animal experiments. [ATSDR ToxProfiles] See "Phenylhydrazine."

Biomedical References

0.00044 mm Hg

Explanatory Notes

VP from HSDB;

Reference Link #2

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Anticipated human carcinogen

Other Information

No other related information on this agent was found.