Agent Name
CAS Number
Major Category
Biological Agents
Coumarin formula graphical representation
1,2-Benzopyrone; 2-Oxo-1,2-benzopyran; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, delta-lactone; 2-Propenoic acid, 3-(2-hydroxyphenyl)-delta-lactone; 2H-1-Benzopyran, 2-oxo-; 2H-1-Benzopyran-2-one; 2H-Benzo(b)pyran-2-one; 3-(2-Hydroxyphenyl)-2-propenoic delta-lactone; 5,6-Benzo-alpha-pyrone; Benzo-alpha-pyrone; Cinnamic acid, o-hydroxy-, delta-lactone; Coumarin; Coumarinic anhydride; Coumarinic lactone; Cumarin; Kumarin [Czech]; Rattex; Tonka bean camphor; cis-o-Coumaric acid anhydride; cis-o-Coumarinic acid lactone; o-Coumaric acid lactone; o-Hydroxycinnamic acid lactone; o-Hydroxycinnamic lactone; o-Hydroxyzimtsaure-lacton [German]; [ChemIDplus] UN2811
Plant Toxins
Colorless solid with a vanilla odor; [Hawley] Colorless fine plates; [MSDSonline]
Occurs naturally in the tonka beans, Cassia, and lavender oils; [Marks, p. 172] Used in soaps, tobacco, pharmaceuticals, and rubber products; Also used in the fragrance industry and in the electroplating industry to polish chrome-plated steel; Coumarin banned in US since 1954 as a flavor in food, it may contaminate vanilla imported from Mexico and Caribbean countries; [HSDB] The anticoagulant warfarin (Coumadin) is synthesized from 4-hydroxycoumarin and benzalacetone with pyridine as a catalyst; Many coumarins are effective laser dyes; [Ullmann]
Emergency treatment: "Coumarin"; After an ingestion of 4 grams of coumarin, a patient developed muscle paralysis but no cardiovascular effects; Has liver toxicity in rats, but humans are relatively resistant; Not active as an anti-coagulant; [HSDB] A skin irritant; May be a human carcinogen; [ICSC] May cause narcosis and liver damage; [CAMEO] May cause irritation; Harmful if swallowed: causes liver injury and somnolence; [MSDSonline] Coumarin is a fragrance allergen that causes allergic contact dermatitis. [Marks, p. 168, 172]
Biomedical References

Exposure Assessment

Vapor Pressure
0.00098 mm Hg
Explanatory Notes
Flash point = 150 deg C; [ICSC] The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s."

Adverse Effects

Skin Sensitizer
Other CNS neurotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent


Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: