1-Methoxy-2-propyl acetate

Synonyms

1-Methoxy-2-acetoxypropane; 1-Methoxy-2-propanol acetate; 2-Acetoxy-1-methoxypropane; Acetic acid, 2-methoxy-1-methylethyl ester; Dowanol (R) PMA glycol ether acetate; PGMEA; Propylene glycol monomethyl ether acetate; Propyleneglycol monomethyl ether acetate; 2-Methoxy-1-methylethyl acetate; 2-Propanol, 1-methoxy-, 2-acetate; 2-Propanol, 1-methoxy-, acetate; [ChemIDplus] PGMA; [ECHA]

Category

Glycol Ethers (P Series)

Description

Colorless, hygroscopic liquid, with a characteristic odor; [ICSC]

Sources/Uses

Used as a solvent for paints, inks, lacquers, varnishes, cleaners, coatings, ink-removers, and pesticides; [eChemPortal: SIDSUNEP] Used in photoresist formulations in the semiconductor industry; Also used in solvents for degreasing circuit boards and in food contact applications; [CHEMINFO]

Comments

An eye and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] Silk-screen printers were exposed to about 20 ppm; PGMA is not tolerated by workers at concentrations >100 ppm because of objectionable odor and lacrimation. [AIHA] An irritant; [MSDSonline] See "n-Propyl acetate."

Biomedical References

50 ppm

3.92 mm Hg

LC50 (rat) > 5,320 ppm/4h

Explanatory Notes

Flash point = 42 deg C; [ICSC] The ERPG levels apply to both the alpha isomer (108-65-6) and the beta isomer (70657-70-4); [AIHA] VP from ChemIDplus;

high ambient temp required

50 ppm

1,000 ppm

5,000 ppm

50 ppm

Yes

Acute solvent syndrome

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Degreasing
• Painting (Solvents)
• Semiconductor Manufacturing
• Silk-Screen Printing