1,2-Dimethoxyethane

Synonyms

1,2-Ethanediol dimethyl ether; 2,5-Dioxahexane; Ansul ether 121; DME (glycol ether); Dimethyl Cellosolve; Dimethylcellosolve; EGDME; Ethane, 1,2-dimethoxy-; Ethylene dimethyl ether; Ethylene glycol dimethyl ether; Glycol dimethyl ether; Glyme; Hisolve MMM; Monoethylene glycol dimethyl ether; Monoglyme; [ChemIDplus] UN2252

Category

Glycol Ethers (Glymes)

Description

Colorless liquid; [ICSC] Ether-like odor; [Merck Index] Fully miscible; [MSDSonline]

Sources/Uses

Used as a specialty solvent and reagent; [Merck Index] Used in lithium batteries and industrial coatings; [EPA: Initial Risk-Based Prioritization of HPV Chemicals: Monoglyme]

Comments

TLV Basis is hematologic effect and male reproductive & embryo/fetal damage; [ACGIH] 2-Methoxyethanol is a major metaobolite; "The potential health hazard of monoglyme is high based on the results of repeated-dose (blood, thymus, adrenal gland, and testicular degeneration) and developmental (increased fetal death and skeletal effects and decreased fetal body weight) toxicity studies at relatively low doses in animal studies." [EPA: Initial Risk-Based Prioritization of HPV Chemicals: Monoglyme] Reproductive toxin in animal tests; [ICSC] Labeled as "May impair fertility" and "May cause harm to the unborn child" by EU regulations; [Glycol Ethers Online] Inhalation of vapor may cause dizziness or difficulty breathing; [HSDB] A severe skin and eye irritant; [CAMEO] Reproductive toxin and highly flammable; [MSDSonline] See "GLYCOL ETHERS." See "2-Methoxyethanol."

Biomedical References

Yes

0.5 ppm

48 mm Hg

LCLo (rat) = 17,096 ppm/6h

Explanatory Notes

Flash point = -2 deg C; [ICSC] VP from ChemIDplus;

Acute solvent syndrome

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Battery Manufacturing
• Painting (Solvents)