1,6-Diaminohexane

Synonyms

Hexamethylenediamine; 1,6-Diamino-n-hexane; 1,6-Diaminohexane; 1,6-Hexamethylenediamine; 1,6-Hexanediamine; 1,6-Hexanediamine (solution); 1,6-Hexylenediamine; HMDA; Hexane, 1,6-diamino-; [ChemIDplus] UN1783(solution); UN2280(solid)

Category

Amines, Aliphatic

Description

Colorless solid; [Hawley] Hygroscopic; [ICSC] Has an ammonia-like or fishy odor; [CHEMINFO] White solid; [MSDSonline]

Sources/Uses

Used as an intermediate to make polyamides with applications in fiber, plastics, polyurethane coatings and adhesives, specialty nylons (monofilaments and inks), and specialty chemicals (biocides, petroleum additives, and phenol purification); [eChemPortal: SIDSUNEP]

Comments

A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation of high concentrations may cause pulmonary edema; [ICSC] Allergic dermatitis, rhinitis, and asthma were reported in exposed workers. One case of acute hepatitis was reported. In animal experiments, 6 guinea pigs receiving orally 0.02 grams/day for 20-95 days are slowly poisoned and have weight loss, hemolytic anemia, leukopenia, liver damage, and kidney damage; Similar effects are seen in high-dose inhalation studies in rats inhaling 1.25 mg/m3 (0.26 ppm) 4 hours per day for 8 days; [HSDB] Exposed workers complain of skin and respiratory tract irritation; [ACGIH] Does not meet criteria for dermal sensitizer since animal studies were negative and human reports not confirmed; [AIHA] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; [MSDSonline]

Biomedical References

Insufficient data

0.5 ppm

0.4 mm Hg

LC (rat) > 200 ppm/4h

Explanatory Notes

Flash point = 85 deg C; [ICSC]

1 ppm

Hemolytic anemia

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Other Information

No other related information on this agent was found.