Maneb

Synonyms

Farmaneb; Manesan; Manex; Manzate; Nereb; Newspor; [EXTOXNET]

Category

Dithiocarbamates (Pesticide)

Description

Yellow or brown powder; crystals from alcohol; [HSDB]

Sources/Uses

Used to control potato and tomato blights; [EXTOXNET]

Comments

Classified as "practically nontoxic," maneb has an oral LD50 of greater than 5000 mg/kg in rodents. [EXTOXNET] Allergic contact dermatitis in pesticide handlers is most likely due to maneb, carbofuran, carbaryl, captan, folpet, or captafol. [Marks, p. 312] Danger of skin sensitization; [MAK] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] In high-dose reproductive studies of animals, Maneb causes testicular damage, reduced fertility, and birth defects. [Frazier, p. 230-2] Long-term or repeated exposure may result in kidney impairment or manganism; [ICSC] See the agent, "Ethylene thiourea." See "Manganese" and linked occupational diseases.The TLV for manganese is for elemental and inorganic compounds. Maneb is an organic compound containing manganese.

Reference Link #1

Biomedical References

7.5E-08 mm Hg

Explanatory Notes

Maneb is spontaneously combustible. [CAMEO] VP from HSDB;

Reference Link #2

Yes

Parkinsonism

Yes

Yes

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Manganese, chronic toxic effect

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)