Folpet

Synonyms

Cosan T; Faltan; Folnit; Folpel; Ftalan; Fungitrol 11; Intercide TMP; Orthophaltan 50; Orthophaltan; Phthaltan; Sanfol; Spolacid; Trifol; Folpan; Folpex; Phaltan; Vinicoll; Thiophal; [EXTOXNET] 2-((Trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione; Acryptan; Cosan I; ENT 26539; Faltex; Folpel [French]; Fungitrol; Fungitrol II; Murphy's rose fungicide; N-(Trichlor-methylthio)-phthalamid [German]; N-(Trichlormethylthio)phthalimide; N-(Trichloromethanesulphenyl)phthalimide; N-(Trichloromethylthio)phthalimide; Ortho phaltan 50W; Orthophaltan; Phthaltan; Spolacid; Trichlormethylthioimid kyseliny ftalove [Czech]; Trichloromethylthiophthalimide; Troysan anti-mildew O; 1H-Isoindole-1,3(2H)-dione, 2-((trichloromethyl)thio)-; Phthalimide, N-((trichloromethyl)thio)-; [ChemIDplus]

Category

Fungicides

Description

Colorless or white solid; [HSDB] White solid; Technical product is off-white to tan solid; [Reference #2]

Sources/Uses

Primarily used as an agricultural fungicide, but some industrial uses (paints and plastics); [ACGIH] The thiophthalimides are widely used fungicides on seeds, field crops, and stored produce; [EPA Pesticides] Used as a biocide in paints; [Adams, p. 475] Used in the USA as a pesticide on avocados and as a wood preservative; used in Europe on grapes; [Zainal h, Shane S, Que H. Flopet Permeation Through Nitrile Gloves. Appl Occup Environ Hyg 2003;18:658-668] Used in the US as fungicide for avocados, paints, caulking compounds, and wood treatments; [Reference #2] Used in the EU as fungicide for winter wheat, tomatoes, and wine grapes; [EFSA]

Comments

A skin sensitizer in guinea pigs; Sensitization not reported in humans despite wide-scale use; TLV Basis is liver damage and body weight effects; [ACGIH] The thiophthalimides include captan, captafol, and folpet. No systemic poisonings in humans have been reported. [EPA Pesticides] An eye irritant; May cause skin sensitization; Can be absorbed through skin; [ICSC] Rapidly forms the short-lived and highly reactive metabolite thiophosgene in the presence of thiols in tissue and blood; [Reference #2] Birth defects observed at very high doses in one study of hamsters, although negative results seen in studies of mice, rats, rabbits, and monkeys; [REPROTOX] A severe eye irritant and skin sensitizer; No evidence of toxicity to fertility or reproduction in a 2-generation study of rats, but teratogenic effects observed in rabbits; Not genotoxic in vivo but carcinogenic in mice; [EFSA]

Reference Link #1

Biomedical References

No

1 mg/m3, inhalable particulate matter

1.57E-07 mm Hg

LC50 (rat) = 480 mg/m3

Explanatory Notes

VP from HSDB;

Reference Link #2

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Applying Wood Preservatives
• Farming (Pesticides)
• Painting (Pigments, Binders, and Biocides)