Asulam

Synonyms

4-Amino-benzolsulfonyl-methylcarbamat [German]; Asilan; Asulame [ISO-French]; Asulox; Asulox 40; Asulox F; Carbamic acid, sulfanilyl-, methyl ester (7CI)(8CI); Jonnix; M and B 9057; MB 9057; Methyl ((4-aminophenyl)sulfonyl)carbamate; Methyl 4-aminobenzenesulphonyl carbamate; Methyl 4-aminobenzenesulphonylcarbamate; Methyl 4-aminophenylsulphonyl carbamate; Methyl 4-aminophenylsulphonylcarbamate; Methyl N-(4-aminobenzenesulfonyl)carbamate; Methyl sulfanilyl carbamate; Methyl sulfanilylcarbamate; Methyl sulphanilylcarbamate; N(sup 1)-Methoxycarbonylsulfanilamide; Plakin; Carbamic acid, ((4-aminophenyl)sulfonyl)-, methyl ester; [ChemIDplus]

Category

Herbicides, Carbamate

Description

White solid; [Merck Index]

Sources/Uses

Used as selective pre-emergence herbicide mainly on sugarcane; Also used on ornamentals, turf, and other non-cropland; The only registered product is the sodium salt (Asulam-sodium CAS # 2302-17-2) soluble/concentrate liquid; [Reference #1] Available in the EU as aqueous solution of Asulam-sodium equivalent to 400 g/L Asulam; Designed for use on spinach with other food and feed crop, non-cropland, and grassland uses; [EFSA]

Comments

Thyroid follicular hyperplasia observed in male rats at the LOAEL (180 mg/kg/day) following two year chronic feeding study; Other sub-chronic animal studies produced increase in absolute and relative thyroid weights; Considerable reduction in live births per litter observed in two generation study of rats; [Reference #1] A mild skin and moderate eye irritant in rabbits; Solid evidence of skin sensitization in Maximisation test; Targets thyroid and erythrocytes in 90 day rat study; Thyroid identified as target organ in dogs as well; Hematological and histopathological effects consistent with mild anemia noted in chronic rodent studies; Adrenal medullary hyperplasia and limited evidence of carcinogenicity (phaeochromocytoma of higher frequency) observed at highest doses in male rats in chronic studies; Multi-generational rat study produced reduction in litter size (doses >= 5000 ppm); No evidence of teratogenicity, developmental toxicity, or cholinesterase inhibition; [EFSA] See "Asulam-sodium."

Reference Link #1

Biomedical References

1.44E-06 mm Hg

LC50 (rat) > 5,000 mg/m3

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)