2,3-Pentanedione

Synonyms

2,3-Pentadione; Acetyl propionyl; Acetyl propionyl (natural); Acetylpropionyl; [ChemIDplus] UN1224

Category

Aliphatic Ketones, Other

Description

Colorless to dark yellow liquid with a pleasant buttery odor; [Reference #1] Yellow liquid; [Alfa Aesar MSDS]

Sources/Uses

Used as flavoring agent or adjuvant; [FDA] Used as a substitute for diacetyl in food flavoring and food production; [Reference #1]

Comments

A moderate skin irritant; [RTECS] Safe when used as a flavoring agent in food; [JECFA] Due to structural similarities with diacetyl, there are concerns that occupational exposure may lead to a decline in pulmonary function; Airway epithelial damage demonstrated in rats is similar to that caused by diacetyl; [Reference #1] Danger of skin sensitization; [MAK] A skin and strong eye irritant; [Alfa Aesar MSDS] See "Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers." [PMID 27105025] See "Diacetyl." See "2,4-Pentanedione."

Reference Link #1

Biomedical References

0.02 ppm

21.4 mm Hg

2E-05 ppm

Explanatory Notes

Odor threshold from Reference #1; The Guide in the Emergency Response Guidebook is for "Ketones, liquid, n.o.s."

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Bronchiolitis obliterans
• Contact dermatitis, allergic