Plastics & Rubber
4,4'-,2,4'-,2,2'-Diisocyanatodiphenylmethane; Diphenylmethane diisocyanate; Isocyanic acid, methylenediphenylene ester; Benzene, 1,1'-methylenebis(isocyanato-; Crude MDI; Generic MDI; Non-isomeric-specific MDI; [ChemIDplus] 1,1'-Methylenebis(isocyanatobenzene); 2,4'/4,4'-Diphenylmethandiisocyanat; Difenilmetanodiisocianato; Diphenylmetha-4,4'-diisocyanat; Diphenylmethane-4,4'-diisocyanate and isomers; Diphenylmethane-4,4'-diisocyanate; Isocyanic acid, methylenediphenylene ester; MDI; MDI-Gemisch; Methyldiphenyldiisocyanat; [IUCLID] Methylenebis (phenyl isocyanate); [Official Journal of the European Union] MONDUR ML; [Bayer Material Science MSDS] UN3082
Polymeric MDI: Dark amber viscous liquid; Pure 4,4'-MDI: White waxy solid; [CPS&Q: RARs - Final Report] Light to dark yellow liquid with a mild musty odor; mp = 15-20 deg C; [Bayer Material Science MSDS]
Used in the furniture, car, shoe, carpet, refrigerators and freezers, textile, coatings, and construction industries; [IUCLID] Used primarily in the manufacture of rigid polyurethane foams; Other uses include coatings, adhesives, sealants, elastomers, paints, footwear, (semi) flexible and thermoplastic polyurethane foams, polyurethane fibers, and to make particle board and foundry mould cores; [CPS&Q: RARs - Final Report]
This CAS refers not only to isomeric mixtures but also all the specific isomers including those with unique CAS numbers; A skin, eye, and respiratory tract irritant; Allergic contact dermatitis, contact urticaria, asthma, and hypersensitivity pneumonitis reported from occupational exposure; Long term occupational inhalation exposure has demonstrated decreased ventilatory function and respiratory symptoms even at levels below current guidelines; [CPS&Q: RARs - Final Report] Causes contact urticaria; [Kanerva, p. 219] Reacts slowly with water evolving carbon dioxide; An irritant; May cause skin and respiratory sensitization; Inhalation overexposure may cause bronchitis, bronchial spasm, and pulmonary edema; [Bayer Material Science MSDS] See "Methylene bisphenyl isocyanate."
4E-06 mm Hg
Odor Threshold Low
LC50 (rat) = 369 mg/m3/4hr
Odor threshold from IUCLID; The Guide in the Emergency Response Guidebook is for "Other regulated substances, liquid, n.o.s."
Occupational diseases associated with exposure to this agent:
Industrial Processes with risk of exposure: