Ziram

Synonyms

Zinc dimethyldithiocarbamate; (T-4)-Bis(dimethyldithiocarbamato-S,S')zinc (9CI); Aaprotect; Aaprotent; Aavolex; Aazira; Accelerator L; Aceto ZDED; Aceto zdmd; Alcobam ZM; Antene; Bis(N,N-dimetil-ditiocarbammato) di zinco [Italian]; Bis(dimethylcarbamodithioato-S,S')zinc; Bis(dimethyldithiocarbamato)zinc; Bis-dimethyldithiocarbamate de zinc [French]; Carbamic acid, dimethyldithio-, zinc salt (2:1); Carbamodithioic acid, dimethyl-, zinc salt; Carbazinc; Corona corozate; Corozate; Crittam; Crittan; Cuman; Cuman L; Cymate; Dimethylcarbamodithioic acid, zinc complex; Dimethylcarbamodithioic acid, zinc salt; Dimethyldithiocarbamate zinc salt; Dimethyldithiocarbamic acid, zinc salt; Drupina 90; ENT 988; Eptac 1; Fuclasin; Fuclasin Ultra; Fuclasin-ultra; Fuklasin; Fungostop; Hermat ZDM; Hexazir; Karbam White; Methasan; Methazate; Methyl Ziram; Methyl zimate; Methyl zineb; Methyl zineb (VAN); Mezene; Micosin F30; Milbam; Molurame; Mycronil; Nocceler pz; Orchard brand ziram; Pomarsol Z forte; Pomarzol Z-forte; Prodaram; Ramedit; Rhodiacid; Rhodiacid (VAN); Rodisan; Sabceler PZ; Soxinal PZ; Soxinol PZ; Tricarbamix Z; Trikagol; Triscabol; Tsimat; Tsiram [Russian]; Vancide MA-96; Vancide MZ-96; Vulcacure ZM; Vulkacit L; Vulkacite L; Weisstaub; Z 75; Z-C spray; Z-C-Spray; Zarlate; Zerlate; Zimate; Zimate, methyl; Zinc N,N-dimethyldithiocarbamate; Zinc bis(dimethyldithiocarbamate); Zinc bis(dimethyldithiocarbamoyl) disulfide; Zinc bis(dimethyldithiocarbamoyl)disulphide; Zinc bis(dimethylthiocarbamoyl) disulfide; Zinc bis(dimethylthiocarbamoyl)disulfide; Zinc dimethyl dithiocarbamate; Zinc, bis(dimethylcarbamodithioato-S,S')-, (T-4)-; Zinc, bis(dimethyldithiocarbamato)-; Zink-(N,N-dimethyl-dithiocarbamat) [German]; Zink-bis(N,N-dimethyl-dithiocarbamaat) [Dutch]; Zink-bis(N,N-dimethyl-dithiocarbamat) [German]; Zinkcarbamate; Ziradin; Ziram (VAN); Ziram Granuflo; Ziram technical; Zirame; Zirame [ISO-French]; Ziramvis; Zirasan; Zirasan 90; Zirberk; Ziretec; Zirex 90; Zirex Fungicide; Ziride; Zirthane; Zitox; Zinc, bis(dimethylcarbamodithioato-S,S')-; Zinc, bis(dimethylcarbamodithioato-S,S')-, (beta-4)-; Zinc, bis(dimethylcarbamodithioato-kappaS,kappaS')-, (T-4)-; [ChemIDplus] UN2771

Category

Dithiocarbamates (Pesticide)

Description

White solid; [ICSC] White solid; Formulated as water dispensable granules, flowable concentrate, and wettable powder for dust and spray; [Reference #2] White powder; [Aldrich MSDS]

Sources/Uses

Used as a fungicide and rubber accelerator; [Kanerva, p. 1847] Also used in adhesives, paper coatings, industrial cooling water, latex coated items, neoprene, paper and paperboard, plastics, textiles, as bird and rodent repellent, and for control of snails; [HSDB] Used as an agricultural fungicide for stone and pome fruits, nuts, vegetables, turf, ornamentals, and other crops; Also used as a rabbit repellent and in industrial adhesives, paper and paper products, textiles, caulking, latex paints, and wall boards; [Reference #2]

Comments

Allergic contact dermatitis reported in farmworkers; [Kanerva, p. 1847] Danger of skin sensitization; [MAK] The EBCDCs (ethylenebisdithiocarbamates) can cause irritant and allergic contact dermatitis. EBDCs include ferbam, vapam, maneb, mancozeb, zineb, thiram, and ziram. They are also used as rubber accelerators. Ethylene thiourea (ETU), which may contaminate EBCDCs, is carcinogenic and teratogenic in animal experiments. [LaDou, p. 610] ETU is the major metabolite of EBDCs. [Krieger, p. 1690] A skin, respiratory tract, and severe eye irritant; May cause skin sensitization; Tumors observed in experimental animals with unknown relevance to humans; [ICSC] The primary target organs for toxicity seem to be the nervous system, liver, and thyroid; In rats a single oral dose can cause neurological impairment. Histopathology of the liver (sometimes with corresponding increases in hepatic serum enzyme levels) observed in sub-chronic and chronic rat studies and carcinogenicity study of mice; Classified as "suggestive of carcinogenicity" in humans; [Reference #2] See the agent, "Ethylene thiourea."

Reference Link #1

Biomedical References

0.01 mg/m3, inhalable fraction

7.5E-09 mm Hg

LC50 (rat) = 70 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Dithiocarbamate pesticide, solid, toxic." VP = 7.5X10-9 mmHg @ 0 deg C; [HSDB]

Reference Link #2

Yes

Other CNS neurotoxin

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)
• Painting (Pigments, Binders, and Biocides)
• Pulp and Paper Processing
• Textiles (Printing, Dyeing, or Finishing)
• Working with Glues and Adhesives