If left on clothes, may cause reddening of skin; [CHRIS] A case of peripheral neuropathy was reported in a 19 year old male after 2 months of occupational exposure to a degreasing solvent containing 95.5% 1-BP. Reproductive toxicity and hepatotoxicity are observed in animals repeatedly exposed to levels above 250 ppm and 200 ppm, respectively. LOAEL was 1.28 ppm for loss of vibratory sensation in toes and reduced RBC count in 60 factory workers exposed to 1-BP. TLV Basis: CNS impairment; peripheral neuropathy; hematologic effects, reproductive, and developmental toxicity; [ACGIH] 1-BP causes neurotoxicity and reproductive toxicity in animal studies. A study of 27 workers producing 1-BP in a Chinese factory found evidence of toxicity to the CNS and peripheral nerves. [PMID 15345346
] Six cases of neurotoxicity (possible central distal axonopathy) were reported among foam cushion gluers. [PMID 17453879
] A cross-sectional study of 60 female and 26 male workers in three 1-BP factories in China found neurotoxicity in females exposed to >1.28 ppm. [PMID 20657306
] Potential adverse effects include CNS depression and anesthesia; [HSDB] See "Carcinogenicity of some industrial chemicals," Volume 115. [IARC, News Release, 23 February 2016] See "2-Bromopropane."