1-Bromopropane

Synonyms

Propane, 1-bromo-; Propyl bromide; n-Propyl bromide; [ChemIDplus] n-Propylbromide; Propylbromide;1-BP; [ACGIH] UN2344

Category

Brominated Solvents

Description

Colorless liquid; [ACGIH]

Sources/Uses

Used as a solvent substitute "to clean metals and electronics, in adhesive and coating applications, and in aerosol propellant applications." Has also been used to replace perchloroethylene in dry cleaning; [ACGIH]

Comments

If left on clothes, may cause reddening of skin; [CHRIS] A case of peripheral neuropathy was reported in a 19 year old male after 2 months of occupational exposure to a degreasing solvent containing 95.5% 1-BP. Reproductive toxicity and hepatotoxicity are observed in animals repeatedly exposed to levels above 250 ppm and 200 ppm, respectively. LOAEL was 1.28 ppm for loss of vibratory sensation in toes and reduced RBC count in 60 factory workers exposed to 1-BP. TLV Basis: CNS impairment; peripheral neuropathy; hematologic effects, reproductive, and developmental toxicity; [ACGIH] 1-BP causes neurotoxicity and reproductive toxicity in animal studies. A study of 27 workers producing 1-BP in a Chinese factory found evidence of toxicity to the CNS and peripheral nerves. [PMID 15345346] Six cases of neurotoxicity (possible central distal axonopathy) were reported among foam cushion gluers. [PMID 17453879] A cross-sectional study of 60 female and 26 male workers in three 1-BP factories in China found neurotoxicity in females exposed to >1.28 ppm. [PMID 20657306] Potential adverse effects include CNS depression and anesthesia; [HSDB] See "Carcinogenicity of some industrial chemicals," Volume 115. [IARC, News Release, 23 February 2016] See "2-Bromopropane."

Biomedical References

No

0.1 ppm

111 mm Hg

LC50 (rat) =253,000 mg/m3/30 min

Explanatory Notes

VP from ChemIDplus;

Reference Link #2

high ambient temp required

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Possible (2b)

Anticipated human carcinogen

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Neuropathy, toxic
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Dry Cleaning
• Metal Degreasing
• Painting (Solvents)
• Working with Glues and Adhesives