p-Toluenesulfonyl isocyanate
Agent Name
p-Toluenesulfonyl isocyanate
CAS Number
4083-64-1
Formula
C8-H7-N-O3-S
Major Category
Nitrogen Compounds
Synonyms
Benzenesulfonyl isocyanate, 4-methyl-; p-Toluenesulphonyl isocyanate; p-Toluenesulfonic acid, anhydride with isocyanic acid; [ChemIDplus] PTSI; [EPA ChAMP: Submission] Additive TI; Isocyanic acid, anhydride with p-toluenesulfonic acid (6CI); p-Methylbenzenesulfonyl isocyanate; 4-Methylbenzenesulfonyl isocyanate; p-Methylphenylsulfonyl isocyanate; 4-Methylphenylsulfonyl isocyanate; 4-Toluenesulfonyl isocyanate; Tosyl isocyanate; p-Tosyl isocyanate; [RTECS] UN2206
Category
Other Aromatics (Nitrogen)
Description
Colorless liquid with an irritating odor; [Alfa Aesar MSDS]
Sources/Uses
Used in polyurethane coatings, sealants, and adhesives, as a stabilizer for organic isocyanates, and as a chemical intermediate; [EPA ChAMP: Submission] Used to formulate adhesives-sealants and paints-coatings-thinners and as an intermediate for pharmaceuticals; [ExPub: ECHA REACH Registrations]
Comments
A mild skin and moderate eye irritant; Causes changes in leukocyte count and changes in liver and kidney weights in 42-day constant oral studies of rats; [RTECS] Highly reactive; Hydrolyses rapidly forming p-toluenesulfonamide (CAS# 70-55-3) and carbon dioxide; [EPA ChAMP: Submission] Reacts violently with water; A skin and strong eye irritant; May cause respiratory sensitization; [Alfa Aesar MSDS] Search for (4083-64-1[EC/RN Number]) AND (asthma OR dermatitis OR allergic OR sensitizer OR sensitization): no results; [PubMed] See "p-Toluenesulfonamide."
Biomedical References
Exposure Assessment
Lethal Concentration
LC50 (rat) > 640 ppm/1hr
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Isocyanates, toxic, n.o.s."
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: