Toluene diisocyanate

Synonyms

1,3-Diisocyanatomethylbenzene; 2,4/2,6-Toluene diisocyanate isomeric mixture; Benzene, 1,3-diisocyanatomethyl-; Diisocyanatotoluene; Isocyanic acid, methyl-m-phenylene ester; Methyl-m-phenylene isocyanate; Methyl-meta-phenylene diisocyanate; Methylphenylene isocyanate; Nacconate-100; Niax isocyanate TDI; Rubinate TDI; Rubinate TDI 80/20; TDI; TDI 80-20; Tolylene diisocyanate; Tolylene isocyanate; m-Tolylidene diisocyanate; 2,4- and 2,6-Toluene diisocyanate; Toluene-2,4-diisocyanate (mixt. With Toluene-2,6-diisocyanate); Toluenediisocyanate (mixed isomers); [ChemIDplus] VORANATE T-80 Type I TDI; [Dow Chemical MSDS] UN2068

Category

Diisocyanates

Description

Clear colorless to pale yellow liquid with a pungent odor; [HSDB] Colorless to yellow liquid with a sharp odor; mp = 14 deg C; [Dow Chemical MSDS]

Sources/Uses

Used to make polyurethanes, polyurethane foams, elastomers, and coatings, as a cross-linker for nylon-6, and hardener for adhesives and finishes; [HSDB]

Comments

Most commonly produced as a mixture of isomers, with 80% 2,4- and 20% 2,6-isomers; Also available as a mixture of 65% 2,4- and 35% 2,6-isomers; [HSDB] This CAS# is for mixture of toluene-2,4-diisocyanate and toluene-2,6-diisocyanate; Reacts slowly with water evolving carbon dioxide; An irritant; May cause skin and respiratory sensitization; Excessive inhalation exposure may cause severe irritation, pulmonary edema, permanently decreased lung function, neurologic disorders, cholinesterase depression, and gastrointestinal distress; [Dow Chemical MSDS] See "Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States." [PMID 29200134] See "Toluene-2,4-diisocyanate" and "Toluene 2,6-diisocyanate."

Biomedical References

Toluene diamine in urine at end of shift = 5 ug/g creatine; [TLVs and BEIs]

Insufficient data

0.001 ppm, inhalable fraction and vapor

0.005 ppm, inhalable fraction and vapor

Ceiling(OSHA) = 0.02 ppm

0.023 mm Hg

0.05 ppm

LC50 (mouse) = 9.7 ppm/4hr

Explanatory Notes

No major toxicological differences between the various isomers and commercial mixtures of TDI; TLV Basis: asthma; pulmonary function; eye irritation; [ACGIH]

must be preheated

Yes

Yes

Yes

Yes

Skin burns

Possible (2b)

Anticipated human carcinogen

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Painting (Pigments, Binders, and Biocides)
• Plastic Composites Manufacturing
• Working with Glues and Adhesives