It is readily absorbed through GI, pulmonary, and skin routes; it's acute toxicity is due to the release of the cyanide ion in the body; Caused occupational fatalities in the past when it was used as a fumigant; [ACGIH] May cause redness and blisters when spilled on the skin. [ICSC] If left on clothes, can cause reddening of skin; [CHRIS] Allergic contact dermatitis reported in workers producing synthetic fibers; [Kanerva, p. 1746] In reproductive studies of experimental animals, acrylonitrile causes testicular damage and fetal skeletal abnormalities. [Frazier, p. 349-50] ". . . when acrylonitrile exposures were less than those causing overt maternal toxicity, no developmental toxicity was observed." Decreased sperm counts were observed in 30 exposed workers, but the exposures were not quantified. [ACGIH] A lachrymator; [CHEMINFO] "In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up." [PMID 18469624
] Acrylonitrile, stabilized (UN1093) has warning of explosive polymerization; [ERG 2016] See "NITRILES."