Vanadium pentoxide

Agent Name
Vanadium pentoxide
CAS Number
1314-62-1
Formula
O5-V2
Major Category
Metals
Vanadium pentoxide formula graphical representation
Synonyms
Divanadium pentoxide; Vanadic anhydride; Vanadium oxide; Vanadium pentaoxide; [NIOSH] UN2862
Category
Metals, Inorganic Compounds
Description
Yellow-orange powder or dark-gray, odorless flakes dispersed in air; [NIOSH]
Sources/Uses
Vanadium has been measured in fuel oil at 250 to 400 ppm and in Bessemer slag at 10 to 15% of the weight of the total ash. [ACGIH] Flu ash from oil burning furnaces may contain more than 50% vanadium pentoxide; [ILO Encyclo: Vanadium] Vanadium exposure can also occur in workers cleaning coal furnaces, mining, and producing ferrovanadium. Vanadium is used as a polymer catalyst, dye mordant, and ceramic colorant. [LaDou, p. 481]
Comments
Chronic bronchitis has been described in boiler cleaners exposed to vanadium pentoxide. [ACGIH] Green tongue has been reported after local deposition, but it is not a sign of systemic poisoning. [Rosenstock, p. 988] The predominant symptom associated with exposure to vanadium oxide dust is bronchitis. Asthma has been documented in workers exposed to vanadium dust, vanadium pentoxide, and vanadate. [Harber, p. 505] Based on case reports, "boilermaker's bronchitis" is a form of asthma induced by exposure to vanadium in oil tank cleaners. [PMID 6332888; PMID 10086213] In lethal inhalation exposures of rabbits to particle sizes mainly <10 microns, it causes respiratory tract inflammation and pulmonary edema after 205 mg/m3 for 7 hours, but not to 77 mg/m3 for 7 hours or to 525 mg/m3 for 1 hour; [IPCS: Health and Safety Guide No. 42] Acute pneumonitis or pulmonary edema have not been reported after occupational exposure to vanadium; [Harber, Table 29-3, p. 487]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
0.05 mg/m3, inhalable fraction, as V
PEL (OSHA)
Ceiling(OSHA) = 0.5 mg/m3, as V2O5 (respirable dust), 0.1 mg/m3, as V2O5 (fume)
IDLH (NIOSH)
35 mg/m3, as V
Excerpts from Documentation for IDLHs
Human data: Respiratory irritation following exposures to V2O5 ranging from 1 to 48 mg V/m3 has been described in workers [Sjoberg 1955]. Vanadium intoxication (i.e., rhinorrhea, sneezing, lacrimation, and sore throat) has been reported in workers exposed to concentrations of V2O5 during the workshift ranging from 10 to 33 mg/m3 [Williams 1952]. Concentrations of V2O5 exceeding 56 mg V/m3 have resulted in local respiratory effects [Vintinner et al. 1955]. Other workers exposed intermittently to 56 mg V/m3 showed no evidence of intoxication [McTurk et al. 1956].
Lethal Concentration
LC50 (rat) = 126 mg/m3/6H
Half Life
Animal studies: 40% of absorbed dose eliminated in urine within 3 days; [TDR, p. 1212]
Reference Link #2

Adverse Effects

Chronic Bronchitis
Yes
Asthma
Yes
Toxic Pneumonitis
Yes
IARC Carcinogen
Possible (2b)
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Activities

Activities with risk of exposure: