Furfural

Agent Name
Furfural
CAS Number
98-01-1
Formula
C5-H4-O2
Major Category
Other Classes
Furfural formula graphical representation
Synonyms
2-Formylfuran; 2-Formylofuran [Polish]; 2-Furaldehyde; 2-Furanaldehyde; 2-Furancarbonal; 2-Furancarboxaldehyde; 2-Furankarbaldehyd [Czech]; 2-Furfural; 2-Furfuraldehyde; 2-Furil-metanale [Italian]; 2-Furyl-methanal; 2-Furylaldehyde; 2-Furylcarboxaldehyde; Ant Oil, artificial; Artificial ant oil; Artificial oil of ants; Bran oil; Fural; Furaldehyde; Furale; Furancarbonal; Furfural; Furfural (natural); Furfuraldehyde; Furfurale [Italian]; Furfurol; Furfurole; Furfurylaldehyde; Furol; Furole; Furyl-methanal; Pyromucic aldehyde; Quakeral; [ChemIDplus] UN1199
Category
Aldehydes
Description
Colorless to amber liquid with an almond-like odor. [Note: Darkens in light and air.]; [NIOSH]
Sources/Uses
Used in solvent extraction in petroleum refining; used as a solvent for rubber cements, resins, and dyes; also used as a flavoring agent and chemical intermediate; [HSDB] Used to make furan-based chemicals; Decomposes into furan above 250 deg C; Polymerizes into furan-based resins in the presence of strong acid; One of the aldehydes in smoke, e.g., soldering, and present in many foods; "Generally recognized as safe" as a food flavor; Was used in high concentrations as a herbicide and fungicide; [ACGIH]
Comments
Liquid causes first degree burns on short exposure. [CHRIS] At concentrations of 1.9 to 14 ppm, vapor can cause weeping of the eyes. [HSDB] TLV Basis is upper respiratory tract irritation and eye irritation; Hepatotoxicity reported in rats exposed to higher oral doses (30-60 mg/kg); [ACGIH] An irritant that defats the skin and may injure the liver; [ICSC] Vapor is eye and respiratory tract irritant; [CAMEO] Furfuraldehydes (UN1199) has warning of explosive polymerization; [ERG 2016]
Restricted
No longer contained in any registered pesticide products in the United States; [HSDB]
Reference Link #1
Biomedical References

Exposure Assessment

BEI
Furoic acid in urine = 200 mg/L at end of shift; "The determinant is nonspecific, since it is also observed after exposure to other chemicals." [TLVs and BEIs]]
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
0.2 ppm
PEL (OSHA)
5 ppm
IDLH (NIOSH)
100 ppm
Excerpts from Documentation for IDLHs
Human data: Widespread eye and respiratory tract irritation has been noted in workers exposed to concentrations ranging from 5 to 16 ppm [Apol and Lucas 1975]. Headaches, itching of the throat, and red and weeping eyes have occurred at concentrations ranging from 1.9 to 14 ppm [Korenman and Resnik 1930].
Vapor Pressure
2.21 mm Hg
Odor Threshold Low
0.078 ppm
Lethal Concentration
LC50 (rat) = 175 ppm/6H
Explosive Polymerization
Yes
Explanatory Notes
Flash point = 60 deg C, closed cup; [ACGIH] UN1199 is "Furfuraldehydes." [ERG 2016] VP from HSDB;
Reference Link #2
NFPA
high ambient temp required
ERPG-1
2 ppm
ERPG-2
10 ppm
ERPG-3
100 ppm

Adverse Effects

Lachrymator
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent