Agent Name
CAS Number
Major Category
Plastics & Rubber
Acrylamide formula graphical representation
Acrylamide monomer; Acrylic amide; Propenamide; 2-Propenamide; [NIOSH]
Other Monomers
White crystalline, odorless solid; [NIOSH]
Used as a polymer or copolymer to produce sealants, adhesives, fibers, paper sizing, molded parts, water coagulants, and textiles. "In the United States, 90% of acrylamide is used to produce polyacrylamide for water treatment (60%), pulp and paper production (20%) and mineral processing (10%);" [ACGIH]
Can cause sensorimotor neuropathy after occupational exposure; "Polyacrylamide, with less than 0.01% acrylamide, is nontoxic and considered safe as a cosmetic ingredient. . . . Available data indicate no unique sensitivity to the fetus. . . . Most cases of acrylamide poisoning in humans involved exposures over weeks or months from handling the monomer in the course of polymerization. . . . Kim et al. (2017) reported two cases of dermal and neural toxicity in Korean grouting workers with exposure to grouting agents that contained a high concentration of acrylamide (32 and 39% monomer)." [ACGIH] Allergic contact dermatitis reported in laboratory workers using polyacrylamide gels for electrophoresis; [Kanerva, p. 1738] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK] Acrylamide (UN2074) has warning of explosive polymerization; [ERG 2016]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
0.03 mg/m3, inhalable fraction and vapor
0.3 mg/m3
60 mg/m3
Excerpts from Documentation for IDLHs
Calculations based on an oral LD50 of 150 to 180 mg/kg for guinea pigs, rabbits, and rats [McCollister et al. 1964] indicate that a worker should be able to escape within 30 minutes without injury or irreversible health effects from 600 mg/m3. . . . the revised IDLH for acrylamide is 60 mg/m3 based on being 2,000 times the OSHA PEL of 0.03 mg/m3 that was promulgated in 1989 (2,000 is an assigned protection factor for respirators; only the most reliable respirators are recommended above 2,000 times the OSHA PEL). [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for acrylamide at concentrations above 0.03 mg/m3.]
Vapor Pressure
0.007 mm Hg
Explosive Polymerization
Explanatory Notes
VP from HSDB; See 2022 "Notice of Intended Changes" for BEI; [ACGIH TLVs and BEIs]
Half Life
Plasma (animal studies): 2 days; whole body (animal studies): 6-18 days; [TDR, p. 40]
high ambient temp required

Adverse Effects

Skin Sensitizer
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Suspected Human

Diseases, Processes, and Activities Linked to This Agent


Occupational diseases associated with exposure to this agent: