Agent Name
CAS Number
Major Category
Other Classes
Hexachloroethane formula graphical representation
Carbon hexachloride; 1,1,1,2,2,2-Hexachloroethane; Avlothane; Distokal; Distopan; Distopin; Egitol; Ethane hexachloride; Ethane, hexachloro-; Ethylene hexachloride; Falkitol; Fasciolin; Fron 110; Hexachlor-aethan [German]; Hexachlorethane; Hexachloroethane; Hexachloroethylene; Mottenhexe; Perchloroethane; Phenohep; [ChemIDplus] HC; HCE; [HSDB] UN3077
Halogenated Aliphatics, Saturated
Colorless crystals that sublime at 185 deg C and have a camphor-like odor; [Hawley]
Used by the military to make "smoke bombs" and by industry to remove air bubbles from molten aluminum; no longer produced in the United States; [ATSDR ToxFAQs] Used in metallurgy for refining aluminum alloys, removing impurities from molten metals, recovering metal from ores or smelting products, and as degassing agent for magnesium, to inhibit explosiveness of methane and combustion of ammonium perchlorate, in pyrotechnics, fire extinguishing fluids, organic synthesis, as ignition suppressant, polymer additive, flame-proofing agent, vulcanizing agent, swelling agent and to increase dye affinity for polymer fibers, laboratory chemical, plasticizer for cellulose esters, insecticide, rubber process solvent, camphor substitute in nitrocellulose, retardant in fermentation, to make synthetic diamonds, and as veterinary anthelmintic (flukicide); [HSDB] Has also been used in fungicide and insecticide formulations, extreme-pressure lubricants, moth repellents, and submarine paints; [NTP]
Animals exposed to 48 ppm show no adverse effects except respiratory irritation. Feeding rats HCE for 16 weeks results in kidney and liver injury. [ACGIH] Has powerful narcotic effects; Also injures the liver and causes lacrimation on eye contact; [CAMEO] May cause unconsciousness; May have CNS effects, causing tremors and ataxia at high exposure levels; May cause liver and kidney injury; Can be absorbed through skin; [ICSC] A skin, eye, mucous membrane, and upper respiratory tract irritant; A CNS depressant; [HSDB] May cause smarting and reddening of skin if spilled and allowed to remain on clothes; An eye irritant and lachrymator; A strong narcotic and hepatotoxin; May cause nervous system disorders; [CHRIS] A strong irritant; May cause liver and kidney injury; Can be absorbed through skin; Carcinogenic effects observed in animal studies; [Alfa Aesar MSDS]
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
1 ppm
1 ppm
1 ppm
300 ppm
Excerpts from Documentation for IDLHs
Based on the toxicological data relating to potential liver injury [Gleason et al. 1969; Elkins 1959], 300 ppm, the saturated vapor pressure at 20 C [Kirk­Othmer 1964] has been chosen as the IDLH.
Vapor Pressure
0.4 mm Hg
Odor Threshold Low
0.15 ppm
Lethal Concentration
LCLo (rat) = 5,900 ppm/8hr
Explanatory Notes
Odor threshold from CHEMIINFO; The Guide in the Emergency Response Guidebook is for "Environmentally hazardous substances, solid, n.o.s." VP from HSDB;
Half Life
Approximately 2.5 days; [HSDB]

Adverse Effects

Other CNS neurotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
IARC Carcinogen
Possible (2b)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent