Synonyms
Para-cresol; 1-Hydroxy-4-methylbenzene; 1-Methyl-4-hydroxybenzene; 4-Cresol; 4-Hydroxytoluene; 4-Methylphenol; Paramethyl phenol; Phenol, 4-methyl-; p-Cresylic acid; p-Hydroxytoluene; p-Kresol [German]; p-Methylhydroxybenzene; p-Methylphenol; p-Oxytoluene; p-Toluol; p-Tolyl alcohol; para-Cresol; para-Cresylic acid; Phenol, 4-methyl-; Cresol, p-; Cresol, p-isomer; Cresol, para-; [ChemIDplus] p-Methylphenylol; Paracresol; [HSDB] UN2076; UN3455
Description
Solid with a phenolic odor; mp = 35.5 deg C; [Merck Index] Colorless solid that darkens on exposure to light and air; [ICSC] Colorless, white, or pink solid; [NTP] Colorless crystals; [Sigma-Aldrich MSDS]
Sources/Uses
Used as an industrial solvent, to make synthetic resins, and in disinfectants and fungicides; [Merck Index] Used to make explosives, fragrances, antioxidants, lubricating oils, motor oils, rubbers, polymers, elastomers, and other chemicals; Also used as a metal cleaning agent, solvent for wire enamels, ore flotation agent, coal desulfurizing agent, flavoring agent, and in the petroleum, photographic, paint, dye, and agricultural industries; [HSDB] Used in degreasing compounds, paintbrush cleaners, engine cleaners, and in the textile industry; [NTP] Naturally occurring in many plants, human urine, petroleum, and coal tar, as well as emissions from the combustion of wastes, coal, wood, vehicles, and cigarettes; Used primarily as an intermediate for BHT (antioxidant), other antioxidants, anisaldehyde, and other intermediates; Uses for all cresol isomers include as preservatives or stabilizers in cleaning/washing agents, surface treatment products, paints, adhesives, binding agents, corrosion inhibitors, and impregnation materials; [OECD SIDS: m-/p-Cresol Category - 2003]
Comments
Causes burns; Inhalation may cause pulmonary edema; Short-term exposure may have effects on the CNS (lowering of consciousness) and blood (destruction of blood cells); Prolonged or repeated exposure may have effects on the nervous system (impaired functions) and blood (anemia); Can be absorbed through skin; [ICSC] May cause second degree skin burns after a few minutes contact; [CHRIS] The most toxic of the three cresol isomers; May cause skin sensitization; [HSDB] No evidence of skin sensitization in limited studies of humans and guinea pigs using p-cresol and m-/p-cresol; A survey reports hypersensitivity reactions of certain individuals to cresol (unspecified isomer); Neither isomer produced mortality or clinical signs of toxicity following exposure to saturated vapor concentrations, although inhalation of aerosols may be fatal; [OECD SIDS: m-/p-Cresol Category - 2003] Safe when used as a flavoring agent in food; [JECFA] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Highly toxic by inhalation; Toxic by ingestion and skin absorption; Targets the CNS, lungs, liver, kidney, and eyes; [Sigma-Aldrich MSDS] See "Cresol, all isomers."